Ontology highlight
ABSTRACT:
SUBMITTER: Dapp MJ
PROVIDER: S-EPMC5646779 | biostudies-literature | 2017
REPOSITORIES: biostudies-literature
Dapp Michael J MJ Kober Kord M KM Chen Lennie L Westfall Dylan H DH Wong Kim K Zhao Hong H Hall Breana M BM Deng Wenjie W Sibley Thomas T Ghorai Suvankar S Kim Katie K Chen Natalie N McHugh Sarah S Au Lily L Cohen Mardge M Anastos Kathryn K Mullins James I JI
PloS one 20171018 10
Biological sex differences affect the course of HIV infection, with untreated women having lower viral loads compared to their male counterparts but, for a given viral load, women have a higher rate of progression to AIDS. However, the vast majority of data on viral evolution, a process that is clearly impacted by host immunity and could be impacted by sex differences, has been derived from men. We conducted an intensive analysis of HIV-1 gag and env-gp120 evolution taken over the first 6-11 yea ...[more]