Ontology highlight
ABSTRACT:
SUBMITTER: Suzuki S
PROVIDER: S-EPMC1934544 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Suzuki Sayuri S Fukasawa Hirotaka H Kitagawa Kyoko K Uchida Chiharu C Hattori Takayuki T Isobe Tomoyasu T Oda Toshiaki T Misaki Taro T Ohashi Naro N Nakayama Keiko K Nakayama Keiichi I KI Hishida Akira A Yamamoto Tatsuo T Kitagawa Masatoshi M
The American journal of pathology 20070709 2
Ubiquitin-dependent degradation of the cyclin-dependent kinase inhibitor p27 mediated by SCF-Skp2 ubiquitin ligase is involved in cell cycle regulation. Proliferation of tubular cells is a characteristic feature in obstructed kidneys of unilateral ureteral obstruction. Comparing Skp2(+/+) mice with Skp2(-/-) mice, we investigated the involvement of Skp2, a component of SCF-Skp2 ubiquitin ligase for p27, in the progression of renal lesions in unilateral ureteral obstructed kidneys. mRNA expressio ...[more]