Ontology highlight
ABSTRACT:
SUBMITTER: Chabbi-Achengli Y
PROVIDER: S-EPMC3289318 | biostudies-other | 2012 Feb
REPOSITORIES: biostudies-other
Chabbi-Achengli Yasmine Y Coudert Amélie E AE Callebert Jacques J Geoffroy Valérie V Côté Francine F Collet Corinne C de Vernejoul Marie-Christine MC
Proceedings of the National Academy of Sciences of the United States of America 20120130 7
Peripheral serotonin, synthesized by tryptophan hydroxylase-1 (TPH(1)), has been shown to play a key role in several physiological functions. Recently, controversy has emerged about whether peripheral serotonin has any effect on bone density and remodeling.We therefore decided to investigate in detail bone remodeling in growing and mature TPH(1) knockout mice (TPH(1)(-/-)). Bone resorption in TPH(1)(-/-) mice, as assessed by biochemical markers and bone histomorphometry, was markedly decreased a ...[more]