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PERIOD-TIMELESS interval timer may require an additional feedback loop.

ABSTRACT: In this study we present a detailed, mechanism-based mathematical framework of Drosophila circadian rhythms. This framework facilitates a more systematic approach to understanding circadian rhythms using a comprehensive representation of the network underlying this phenomenon. The possible mechanisms underlying the cytoplasmic "interval timer" created by PERIOD-TIMELESS association are investigated, suggesting a novel positive feedback regulatory structure. Incorporation of this additional feedback into a full circadian model produced results that are consistent with previous experimental observations of wild-type protein profiles and numerous mutant phenotypes.

SUBMITTER: Kuczenski RS

PROVIDER: S-EPMC1937016 | biostudies-literature | 2007 Aug

REPOSITORIES: biostudies-literature

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PERIOD-TIMELESS interval timer may require an additional feedback loop.

Kuczenski Robert S RS Hong Kevin C KC García-Ojalvo Jordi J Lee Kelvin H KH

PLoS computational biology 20070801 8

In this study we present a detailed, mechanism-based mathematical framework of Drosophila circadian rhythms. This framework facilitates a more systematic approach to understanding circadian rhythms using a comprehensive representation of the network underlying this phenomenon. The possible mechanisms underlying the cytoplasmic "interval timer" created by PERIOD-TIMELESS association are investigated, suggesting a novel positive feedback regulatory structure. Incorporation of this additional feedb ...[more]

PMID: 17676950

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