Ontology highlight
ABSTRACT:
SUBMITTER: Kuczenski RS
PROVIDER: S-EPMC1937016 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Kuczenski Robert S RS Hong Kevin C KC García-Ojalvo Jordi J Lee Kelvin H KH
PLoS computational biology 20070801 8
In this study we present a detailed, mechanism-based mathematical framework of Drosophila circadian rhythms. This framework facilitates a more systematic approach to understanding circadian rhythms using a comprehensive representation of the network underlying this phenomenon. The possible mechanisms underlying the cytoplasmic "interval timer" created by PERIOD-TIMELESS association are investigated, suggesting a novel positive feedback regulatory structure. Incorporation of this additional feedb ...[more]