Ontology highlight
ABSTRACT:
SUBMITTER: Gao J
PROVIDER: S-EPMC1941505 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Gao Jiangang J Wang Xiang X Wu Xudong X Aguinaga Sal S Huynh Kristin K Jia Shuping S Matsuda Keiji K Patel Manish M Zheng Jing J Cheatham Maryann M He David Z DZ Dallos Peter P Zuo Jian J
Proceedings of the National Academy of Sciences of the United States of America 20070718 30
The remarkable sensitivity and frequency selectivity of the mammalian cochlea is attributed to a unique amplification process that resides in outer hair cells (OHCs). Although the mammalian-specific somatic motility is considered a substrate of cochlear amplification, it has also been proposed that somatic motility in mammals simply acts as an operating-point adjustment for the ubiquitous stereocilia-based amplifier. To address this issue, we created a mouse model in which a mutation (C1) was in ...[more]