Ontology highlight
ABSTRACT:
SUBMITTER: Yablonski D
PROVIDER: S-EPMC19450 | biostudies-literature | 1996 Nov
REPOSITORIES: biostudies-literature
Yablonski D D Marbach I I Levitzki A A
Proceedings of the National Academy of Sciences of the United States of America 19961101 24
The mitogen-activated protein kinase cascade of the Saccharomyces cerevisiae pheromone response pathway is organized on the Ste5 protein, which binds each of the kinases of the cascade prior to signaling. In this study, a structure-function analysis of Ste5 deletion mutants uncovered new functional domains of the Ste5 protein and revealed that Ste5 dimerizes during the course of normal signal transduction. Dimerization, mediated by two regions in the N-terminal half of Ste5, was first suggested ...[more]