Ontology highlight
ABSTRACT:
SUBMITTER: Chaudhri VK
PROVIDER: S-EPMC2801257 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Chaudhri Virendra K VK Kumar Dhiraj D Misra Manjari M Dua Raina R Rao Kanury V S KV
The Journal of biological chemistry 20091106 2
We mathematically modeled the receptor-dependent mitogen-activated protein kinase (MAPK) signaling by incorporating the regulation through cellular phosphatases. Activation induced the alignment of a phosphatase cascade in parallel with the MAPK pathway. A novel regulatory motif was, thus, generated, providing for the combinatorial control of each MAPK intermediate. This ensured a non-linear mode of signal transmission with the output being shaped by the balance between the strength of input sig ...[more]