Ontology highlight
ABSTRACT:
SUBMITTER: Chantalat S
PROVIDER: S-EPMC194885 | biostudies-literature | 2003 Jun
REPOSITORIES: biostudies-literature
Chantalat Sophie S Courbeyrette Régis R Senic-Matuglia Francesca F Jackson Catherine L CL Goud Bruno B Peyroche Anne A
Molecular biology of the cell 20030307 6
The Sec7 domain guanine nucleotide exchange factors (GEFs) for the GTPase ARF are highly conserved regulators of membrane dynamics and protein trafficking. The interactions of large ARF GEFs with cellular membranes for localization and/or activation are likely to participate in regulated recruitment of ARF and effectors. However, these interactions remain largely unknown. Here we characterize Gmh1p, the first Golgi transmembrane-domain partner of any of the high-molecular-weight ARF-GEFs. Gmh1p ...[more]