Ontology highlight
ABSTRACT:
SUBMITTER: Fierro A
PROVIDER: S-EPMC1949415 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Fierro Angélica A Osorio-Olivares Mauricio M Cassels Bruce K BK Edmondson Dale E DE Sepúlveda-Boza Silvia S Reyes-Parada Miguel M
Bioorganic & medicinal chemistry 20070522 15
Four enantiomerically pure (S)-4-alkylthioamphetamine derivatives were evaluated as monoamine oxidase (MAO) inhibitors using the human and rat isoforms of the enzyme. Molecular dockings were performed in order to gain insights regarding the binding mode of these inhibitors. All compounds were potent and selective MAO-A inhibitors although different rank orders of potencies were observed against the enzymes from different species. This behavior can be rationalized on the basis of different bindin ...[more]