Ontology highlight
ABSTRACT:
SUBMITTER: Binda C
PROVIDER: S-EPMC3263826 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Binda Claudia C Aldeco Milagros M Geldenhuys Werner J WJ Tortorici Marcello M Mattevi Andrea A Edmondson Dale E DE
ACS medicinal chemistry letters 20111001 1
The widely employed anti-diabetic drug pioglitazone (Actos) is shown to be a specific and reversible inhibitor of human monoamine oxidase B (MAO B). The crystal structure of the enzyme-inhibitor complex shows the R-enantiomer is bound with the thiazolidinedione ring near the flavin. The molecule occupies both substrate and entrance cavities of the active site establishing non-covalent interactions with the surrounding amino acids. These binding properties differentiate pioglitazone from the clin ...[more]