Ontology highlight
ABSTRACT:
SUBMITTER: Volk DE
PROVIDER: S-EPMC1950219 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Volk David E DE Lee Yi-Chien YC Li Xin X Thiviyanathan Varatharasa V Gromowski Gregory D GD Li Li L Lamb Ashley R AR Beasley David W C DW Barrett Alan D T AD Gorenstein David G DG
Virology 20070329 1
The disease dengue (DEN) is caused by four serologically related viruses termed DEN1, DEN2, DEN3 and DEN4. The structure of the ectodomain of the envelope protein has been determined previously for DEN2 and DEN3 viruses. Using NMR spectroscopic methods, we solved the solution structure of domain III (ED3), the receptor-binding domain, of the envelope protein of DEN4 virus, human strain 703-4. The structure shows that the nine amino acid changes in ED3 that separate the sylvatic and human DEN4 st ...[more]