Ontology highlight
ABSTRACT:
SUBMITTER: Gandham SH
PROVIDER: S-EPMC4272640 | biostudies-literature | 2014 Oct
REPOSITORIES: biostudies-literature
Biochemical and biophysical research communications 20140926 3
Thioaptamers targeting the dengue-2 virus (DENV-2) envelope protein domain III (EDIII) were developed. EDIII, which contains epitopes for binding neutralizing antibodies, is the putative host-receptor binding domain and is thus an attractive target for development of vaccines, anti-viral therapeutic and diagnostic agents. Thioaptamer DENTA-1 bound to DENV-2 EDIII adjacent to a known neutralizing antibody binding site with a dissociation constant of 154nM. ...[more]