Ontology highlight
ABSTRACT:
SUBMITTER: Harris TJ
PROVIDER: S-EPMC1950292 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Harris Tony J C TJ Peifer Mark M
Developmental cell 20070501 5
Tissue morphogenesis requires assembling and disassembling individual cell-cell contacts without losing epithelial integrity. This requires dynamic control of adherens junction (AJ) positioning around the apical domain, but the mechanisms involved are unclear. We show that atypical Protein Kinase C (aPKC) is required for symmetric AJ positioning during Drosophila embryogenesis. aPKC is dispensable for initial apical AJ recruitment, but without aPKC, AJs form atypical planar-polarized puncta at g ...[more]