Ontology highlight
ABSTRACT:
SUBMITTER: Hong S
PROVIDER: S-EPMC2840517 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Hong Soonjin S Troyanovsky Regina B RB Troyanovsky Sergey M SM
Proceedings of the National Academy of Sciences of the United States of America 20100202 8
The homeostasis of adherens junctions was studied using E-cadherin and its two mutants tagged by the photoconvertible protein Dendra2 in epithelial A-431 cells and in CHO cells lacking endogenous cadherin. The first mutant contained point mutations of two elements, Lys738 and the dileucine motif that suppressed cadherin endocytosis. The second mutant contained, in addition, an extensive truncation that uncoupled the mutant from beta-catenin and p120. Surprisingly, the intact cadherin and its tru ...[more]