Ontology highlight
ABSTRACT:
SUBMITTER: Araud T
PROVIDER: S-EPMC1950554 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Araud Tanguy T Genolet Raphael R Jaquier-Gubler Pascale P Curran Joseph J
Nucleic acids research 20070625 14
The expression of cellular proteins that play central roles in the regulation of cell growth and differentiation is frequently tightly controlled at the level of translation initiation. In this article, we provide evidence that the ETS domain transcription factor ELK-1 forms part of this class of genes. Its mRNA 5' UTR is composed of a complexed mosaic of elements, including uAUGs, uORFs and RNA structure, that interplay to modulate ribosomal access to the ELK-1 AUG start codon. Superimposed upo ...[more]