Ontology highlight
ABSTRACT:
SUBMITTER: Glas J
PROVIDER: S-EPMC1950565 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Glas Jürgen J Seiderer Julia J Wetzke Martin M Konrad Astrid A Török Helga-Paula HP Schmechel Silke S Tonenchi Laurian L Grassl Christine C Dambacher Julia J Pfennig Simone S Maier Kerstin K Griga Thomas T Klein Wolfram W Epplen Jörg T JT Schiemann Uwe U Folwaczny Christian C Lohse Peter P Göke Burkhard B Ochsenkühn Thomas T Müller-Myhsok Bertram B Folwaczny Matthias M Mussack Thomas T Brand Stephan S
PloS one 20070905 9
<h4>Background</h4>The IL23R gene has been identified as a susceptibility gene for inflammatory bowel disease (IBD) in the North American population. The aim of our study was to test this association in a large German IBD cohort and to elucidate potential interactions with other IBD genes as well as phenotypic consequences of IL23R variants.<h4>Methods</h4>Genomic DNA from 2670 Caucasian individuals including 833 patients with Crohn's disease (CD), 456 patients with ulcerative colitis (UC), and ...[more]