Ontology highlight
ABSTRACT:
SUBMITTER: Lundstedt AC
PROVIDER: S-EPMC1950574 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Lundstedt Ann-Charlotte AC McCarthy Shane S Gustafsson Mattias C U MC Godaly Gabriela G Jodal Ulf U Karpman Diana D Leijonhufvud Irene I Lindén Carin C Martinell Jeanette J Ragnarsdottir Bryndis B Samuelsson Martin M Truedsson Lennart L Andersson Björn B Svanborg Catharina C
PloS one 20070905 9
<h4>Background</h4>For unknown reasons, urinary tract infections (UTIs) are clustered in certain individuals. Here we propose a novel, genetically determined cause of susceptibility to acute pyelonephritis, which is the most severe form of UTI. The IL-8 receptor, CXCR1, was identified as a candidate gene when mIL-8Rh mutant mice developed acute pyelonephritis (APN) with severe tissue damage.<h4>Methods and findings</h4>We have obtained CXCR1 sequences from two, highly selected APN prone patient ...[more]