Responses of wild-type and resistant strains of the hyperthermophilic bacterium Thermotoga maritima to chloramphenicol challenge.
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ABSTRACT:
SUBMITTER: Montero CI
PROVIDER: S-EPMC1951032 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Publications
Responses of wild-type and resistant strains of the hyperthermophilic bacterium Thermotoga maritima to chloramphenicol challenge.
Montero Clemente I CI Johnson Matthew R MR Chou Chung-Jung CJ Conners Shannon B SB Geouge Sarah G SG Tachdjian Sabrina S Nichols Jason D JD Kelly Robert M RM
Applied and environmental microbiology 20070608 15
Transcriptomes and growth physiologies of the hyperthermophile Thermotoga maritima and an antibiotic-resistant spontaneous mutant were compared prior to and following exposure to chloramphenicol. While the wild-type response was similar to that of mesophilic bacteria, reduced susceptibility of the mutant was attributed to five mutations in 23S rRNA and phenotypic preconditioning to chloramphenicol. ...[more]
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