Ontology highlight
ABSTRACT:
SUBMITTER: Votteler J
PROVIDER: S-EPMC1951402 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Votteler Jörg J Studtrucker Nicole N Sörgel Stefan S Münch Jan J Rücker Elke E Kirchhoff Frank F Schick Bernhard B Henklein Peter P Fossen Torgils T Bruns Karsten K Sharma Alok A Wray Victor V Schubert Ulrich U
Journal of virology 20070606 17
Mutational analysis of the four conserved proline residues in human immunodeficiency virus type 1 (HIV-1) Vpr reveals that only Pro-35 is required for efficient replication of R5-tropic, but not of X4-tropic, viruses in human lymphoid tissue (HLT) cultivated ex vivo. While Vpr-mediated apoptosis and G(2) cell cycle arrest, as well as the expression and subcellular localization of Vpr, were independent, the capacity for encapsidation of Vpr into budding virions was dependent on Pro-35. (1)H nucle ...[more]