Ontology highlight
ABSTRACT:
SUBMITTER: Venkatachari NJ
PROVIDER: S-EPMC2894018 | biostudies-literature | 2010 Jun
REPOSITORIES: biostudies-literature
Venkatachari Narasimhan J NJ Walker Leah A LA Tastan Oznur O Le Thien T Dempsey Timothy M TM Li Yaming Y Yanamala Naveena N Srinivasan Alagarsamy A Klein-Seetharaman Judith J Montelaro Ronald C RC Ayyavoo Velpandi V
Virology journal 20100607
HIV-1 Vpr, a nonstructural viral protein associated with virus particles, has a positive role in the efficient transport of PIC into the nucleus of non-dividing target cells and enhances virus replication in primary T cells. Vpr is a 96 amino acid protein and the structure by NMR shows three helical domains. Vpr has been shown to exist as dimers and higher order oligomers. Considering the multifunctional nature of Vpr, the contribution of distinct helical domains to the dimer/oligomer structure ...[more]