Ontology highlight
ABSTRACT:
SUBMITTER: Lian S
PROVIDER: S-EPMC1951753 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Molecular biology of the cell 20070627 9
Gene silencing using small interfering RNA (siRNA) is a valuable laboratory tool and a promising approach to therapeutics for a variety of human diseases. Recently, RNA interference (RNAi) has been linked to cytoplasmic GW bodies (GWB). However, the correlation between RNAi and the formation of GWB, also known as mammalian processing bodies, remains unclear. In this report, we show that transfection of functional siRNA induced larger and greater numbers of GWB. This siRNA-induced increase of GWB ...[more]