Two ABC transporter operons and the antimicrobial resistance gene mtrF are pilT responsive in Neisseria gonorrhoeae.
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ABSTRACT:
SUBMITTER: Friedrich A
PROVIDER: S-EPMC1951848 | biostudies-literature | 2007 Jul
REPOSITORIES: biostudies-literature
Publications
Two ABC transporter operons and the antimicrobial resistance gene mtrF are pilT responsive in Neisseria gonorrhoeae.
Friedrich Alexandra A Arvidson Cindy G CG Shafer William M WM Lee Eun-Hee EH So Magdalene M
Journal of bacteriology 20070511 14
Retraction of type IV pili is mediated by PilT. We show that loss of pilT function leads to upregulation of mtrF (multiple transferable resistance) and two operons encoding putative ABC transporters in Neisseria gonorrhoeae MS11. This effect occurs indirectly through the transcriptional regulator FarR, which until now has been shown to regulate only farAB. L-Glutamine can reverse pilT downregulation of the ABC transporter operons and mtrF. ...[more]
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