Ontology highlight
ABSTRACT:
SUBMITTER: Vincent J
PROVIDER: S-EPMC1952403 | biostudies-literature | 2005 Jan
REPOSITORIES: biostudies-literature
Vincent Jeremy J Shan Li L Fan Ming M Brunzelle Joseph S JS Forman Barry M BM Fernandez Elias J EJ
Acta crystallographica. Section F, Structural biology and crystallization communications 20041224 Pt 1
The constitutive androstane receptor (CAR) is a member of the nuclear receptor superfamily. In contrast to classical nuclear receptors, which possess small-molecule ligand-inducible activity, CAR exhibits constitutive transcriptional activity in the apparent absence of ligand. CAR is among the most important transcription factors; it coordinately regulates the expression of microsomal cytochrome P450 genes and other drug-metabolizing enzymes. The murine CAR ligand-binding domain (LBD) was coexpr ...[more]