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5α-Androst-3-en-17β-yl acetate.

ABSTRACT: In the crystal structure of the title compound, C(21)H(32)O(2), ring A is highly distorted, with a conformation inter-mediate between 10β-sofa and 1α,10β-half chair; rings B and C have slightly flattened chair conformations. Ring D assumes an unusual 13β-envelope conformation, probably induced by the acet-oxy substituent. Cohesion of the crystal structure is due only to weak van der Waals inter-actions.

SUBMITTER: Andrade LC

PROVIDER: S-EPMC2979999 | biostudies-literature |

REPOSITORIES: biostudies-literature

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3α,4α-Ep-oxy-5α-androstan-17β-yl acetate.

Project description:The title compound, C(21)H(32)O(3), results from modifications of the A and D rings of the aromatase substrate androstenedione. Ring A adopts a conformation between 10β-sofa and 1α,10β half-chair. Rings B and C are in slightly flattened chair conformations. Ring D approaches a 13β-envelope conformation, probably due to the acet-oxy substituent, and shows a very short Csp(3)-Csp(3) bond next to the epoxide ring, which is characteristic of 3-4 epoxides. .

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Project description:The title hydrated tetrol, C(19)H(32)O(4)·3H(2)O, was synthesized by stereoselective reduction of the compound 3β,5α,6β-trihy-droxy-androstan-17-one. All rings are fused trans. The organic mol-ecules are connected head-to-tail along the c axis via O-H⋯O hydrogen bonds. Layers of water mol-ecules in the ab plane inter-connect these chains. A quantum chemical ab initio Roothan Hartree-Fock calculation of the isolated mol-ecule gives values for the mol-ecular geometry close to experimentally determined ones, apart from the C-O bond lengths, whose calculated values are significantly smaller than the measured ones, probably a consequence of the involvement of the C-OH groups in the hydrogen-bonding network.

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6β-Methyl-3,20-dioxopregn-4-en-17-yl acetate.

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Effect of a synthetic steroid 5α-androst-3β, 5α, 6β-triol on gene expression in irradiated BV2 cells

Project description:We aimed to study the potential role and underlying mechanism of 5α-androst-3β, 5α, 6β-triol on irradiated BV2 cells. We established radiation induced BV2 cells injury model and pretreated with 5α-androst-3β, 5α, 6β-triol or vehicle. We then performed gene expression profiling analysis using data obtained from RNA-seq of different groups.

2024-04-18 | GSE230636 | GEO

3-(2,4-Dichloro-phen-yl)-2-oxo-1-oxaspiro-[4.5]dec-3-en-4-yl acetate.

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Project description:In the title compound, C(21)H(30)N(2)O, there are five fused rings. The A and C rings adopt chair conformations, ring B adopts an 8?,9?-half-chair conformation and ring D adopts a 14?-envelope conformation. The pyrazole ring is planar. Inter-molecular O-H?N hydrogen bonds [H?N = 1.88?(5)?Å] help to stabilize the crystal structure. The absolute structure was deduced from those of the starting materials.

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(E)-2-Meth-oxy-4-(3-oxobut-1-en-yl)phenyl acetate.

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