Lsh controls Hox gene silencing during development.
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ABSTRACT:
SUBMITTER: Xi S
PROVIDER: S-EPMC1955459 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Publications
Lsh controls Hox gene silencing during development.
Xi Sichuan S Zhu Heming H Xu Hong H Schmidtmann Anja A Geiman Theresa M TM Muegge Kathrin K
Proceedings of the National Academy of Sciences of the United States of America 20070828 36
Polycomb-mediated repression and DNA methylation are important epigenetic mechanisms of gene silencing. Recent evidence suggests a functional link between the polycomb repressive complex (PRC) and Dnmts in cancer cells. Here we provide evidence that Lsh, a regulator of DNA methylation, is also involved in normal control of PRC-mediated silencing during embryogenesis. We demonstrate that Lsh, a SNF2 homolog, can associate with some Hox genes and regulates Dnmt3b binding, DNA methylation, and sile ...[more]
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