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Silencing of an abdominal Hox gene during early development is correlated with limb development in a crustacean trunk.

ABSTRACT: We tested whether Artemia abd-A could repress limbs in Drosophila embryos, and found that although abd-A transcripts were produced, ABD-A protein was not. Similarly, developing Artemia epidermal cells showed expression of abd-A transcripts without accumulation of ABD-A protein. This finding in Artemia reveals a new variation in Hox gene function that is associated with morphological evolution. In this case, a HOX protein expression pattern is completely absent during early development, although the HOX protein is expressed at later stages in the central nervous system in a "homeotic-like" pattern. The combination of an absence of ABD-A protein expression in the Artemia limb primordia and the weak repressive function of Artemia UBX protein on the limb-promoting gene Dll are likely to be two reasons why homonomous limbs develop throughout the entire Artemia trunk.

SUBMITTER: Hsia CC

PROVIDER: S-EPMC2893884 | biostudies-literature | 2010 Mar-Apr

REPOSITORIES: biostudies-literature

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Silencing of an abdominal Hox gene during early development is correlated with limb development in a crustacean trunk.

Hsia Cheryl C CC Paré Adam C AC Hannon Michael M Ronshaugen Matthew M McGinnis William W

Evolution & development 20100301 2

We tested whether Artemia abd-A could repress limbs in Drosophila embryos, and found that although abd-A transcripts were produced, ABD-A protein was not. Similarly, developing Artemia epidermal cells showed expression of abd-A transcripts without accumulation of ABD-A protein. This finding in Artemia reveals a new variation in Hox gene function that is associated with morphological evolution. In this case, a HOX protein expression pattern is completely absent during early development, although ...[more]

PMID: 20433454

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