Ontology highlight
ABSTRACT:
SUBMITTER: Athea Y
PROVIDER: S-EPMC1955690 | biostudies-literature | 2007 Mar
REPOSITORIES: biostudies-literature
Athéa Yoni Y Viollet Benoît B Mateo Philippe P Rousseau Delphine D Novotova Marta M Garnier Anne A Vaulont Sophie S Wilding James R JR Grynberg Alain A Veksler Vladimir V Hoerter Jacqueline J Ventura-Clapier Renée R
Diabetes 20070301 3
AMP-activated protein kinase (AMPK) plays an important role in controlling energy homeostasis and is envisioned as a promising target to treat metabolic disorders. In the heart, AMPK is involved in short-term regulation and in transcriptional control of proteins involved in energy metabolism. Here, we investigated whether deletion of AMPKalpha2, the main cardiac catalytic isoform, alters mitochondrial function and biogenesis. Body weight, heart weight, and AMPKalpha1 expression were similar in c ...[more]