Ontology highlight
ABSTRACT:
SUBMITTER: Fielitz J
PROVIDER: S-EPMC1957544 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
The Journal of clinical investigation 20070901 9
Maintenance of skeletal and cardiac muscle structure and function requires precise control of the synthesis, assembly, and turnover of contractile proteins of the sarcomere. Abnormalities in accumulation of sarcomere proteins are responsible for a variety of myopathies. However, the mechanisms that mediate turnover of these long-lived proteins remain poorly defined. We show that muscle RING finger 1 (MuRF1) and MuRF3 act as E3 ubiquitin ligases that cooperate with the E2 ubiquitin-conjugating en ...[more]