Ontology highlight
ABSTRACT:
SUBMITTER: Pertici I
PROVIDER: S-EPMC6117265 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Nature communications 20180830 1
The contraction of striated muscle (skeletal and cardiac muscle) is generated by ATP-dependent interactions between the molecular motor myosin II and the actin filament. The myosin motors are mechanically coupled along the thick filament in a geometry not achievable by single-molecule experiments. Here we show that a synthetic one-dimensional nanomachine, comprising fewer than ten myosin II dimers purified from rabbit psoas, performs isometric and isotonic contractions at 2 mM ATP, delivering a ...[more]