Ontology highlight
ABSTRACT:
SUBMITTER: Hua QX
PROVIDER: S-EPMC196032 | biostudies-literature | 2003 Apr
REPOSITORIES: biostudies-literature
Hua Qing-Xin QX Nakagawa Satoe H SH Wilken Jill J Ramos Rowena R RR Jia Wenhua W Bass Joseph J Weiss Michael A MA
Genes & development 20030321 7
Caenorhabditis elegans contains a family of putative insulin-like genes proposed to regulate dauer arrest and senescence. These sequences often lack characteristic sequence features of human insulin essential for its folding, structure, and function. Here, we describe the structure and receptor-binding properties of INS-6, a single-chain polypeptide expressed in specific neurons. Despite multiple nonconservative changes in sequence, INS-6 recapitulates an insulin-like fold. Although lacking clas ...[more]