Endocytic trafficking of CFTR in health and disease.

ABSTRACT: The cystic fibrosis transmembrane conductance regulator (CFTR) is a Cl-selective anion channel expressed in epithelial tissues. Mutations in CFTR lead to the genetic disease cystic fibrosis (CF). Within each epithelial cell, CFTR interacts with a large number of transient macromolecular complexes, many of which are involved in the trafficking and targeting of CFTR. Understanding how these complexes regulate the trafficking and fate of CFTR, provides a singular insight not only into the patho-physiology of cystic fibrosis, but also provides potential drug targets to help cure this debilitating disease.

SUBMITTER: Ameen N 

PROVIDER: S-EPMC1964799 | biostudies-literature | 2007 Jan

REPOSITORIES: biostudies-literature