Ontology highlight
ABSTRACT:
SUBMITTER: Kadiu I
PROVIDER: S-EPMC3184214 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Kadiu Irena I Nowacek Ari A McMillan Joellyn J Gendelman Howard E HE
Nanomedicine (London, England) 20110321 6
<h4>Aim</h4>Nanoformulated antiretroviral therapy can improve drug compliance for people infected with HIV. Additional benefits would include specific drug deliveries to viral reservoirs and reduction in systemic toxicities.<h4>Methods</h4>In this article, we describe mechanisms of crystalline antiretroviral nanoparticle (NP) uptake, intracellular trafficking and release in human monocyte-derived macrophages.<h4>Results</h4>Following clathrin-dependent endocytosis NPs bypassed lysosomal degradat ...[more]