Ontology highlight
ABSTRACT:
SUBMITTER: Feng L
PROVIDER: S-EPMC1964828 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Feng Lin L Xie Xiaoduo X Ding Qiurong Q Luo Xiaolin X He Jing J Fan Fengjuan F Liu Weizhong W Wang Zhenzhen Z Chen Yan Y
Proceedings of the National Academy of Sciences of the United States of America 20070827 36
Subcellular compartmentalization has become an important theme in cell signaling such as spatial regulation of Ras by RasGRP1 and MEK/ERK by Sef. Here, we report spatial regulation of Raf kinase by RKTG (Raf kinase trapping to Golgi). RKTG is a seven-transmembrane protein localized at the Golgi apparatus. RKTG expression inhibits EGF-stimulated ERK and RSK phosphorylation, blocks NGF-mediated PC12 cell differentiation, and antagonizes Ras- and Raf-1-stimulated Elk-1 transactivation. Through inte ...[more]