Ontology highlight
ABSTRACT:
SUBMITTER: Lucent D
PROVIDER: S-EPMC1965530 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Lucent Del D Vishal V V Pande Vijay S VS
Proceedings of the National Academy of Sciences of the United States of America 20070611 25
Although most experimental and theoretical studies of protein folding involve proteins in vitro, the effects of spatial confinement may complicate protein folding in vivo. In this study, we examine the folding dynamics of villin (a small fast folding protein) with explicit solvent confined to an inert nanopore. We have calculated the probability of folding before unfolding (P(fold)) under various confinement regimes. Using P(fold) correlation techniques, we observed two competing effects. Confin ...[more]