Ontology highlight
ABSTRACT:
SUBMITTER: Nilssen EA
PROVIDER: S-EPMC196876 | biostudies-literature | 2003 Sep
REPOSITORIES: biostudies-literature
Nilssen Esben A EA Synnes Marianne M Kleckner Nancy N Grallert Beáta B Boye Erik E
Proceedings of the National Academy of Sciences of the United States of America 20030905 19
G1 is a crucial phase of cell growth because the decision to begin another mitotic cycle is made during this period. Occurrence of DNA damage in G1 poses a particular challenge, because replication of damaged DNA can be deleterious and because no sister chromatid is present to provide a template for recombinational repair. We therefore have studied the response of Schizosaccharomyces pombe cells to UV irradiation in early G1 phase. We find that irradiation results in delayed progression through ...[more]