Ontology highlight
ABSTRACT:
SUBMITTER: Tesco G
PROVIDER: S-EPMC1973166 | biostudies-literature | 2007 Jun
REPOSITORIES: biostudies-literature
Tesco Giuseppina G Koh Young Ho YH Kang Eugene L EL Cameron Andrew N AN Das Shinjita S Sena-Esteves Miguel M Hiltunen Mikko M Yang Shao-Hua SH Zhong Zhenyu Z Shen Yong Y Simpkins James W JW Tanzi Rudolph E RE
Neuron 20070601 5
Beta-site APP-cleaving enzyme (BACE) is required for production of the Alzheimer's disease (AD)-associated Abeta protein. BACE levels are elevated in AD brain, and increasing evidence reveals BACE as a stress-related protease that is upregulated following cerebral ischemia. However, the molecular mechanism responsible is unknown. We show that increases in BACE and beta-secretase activity are due to posttranslational stabilization following caspase activation. We also found that during cerebral i ...[more]