Ontology highlight
ABSTRACT:
SUBMITTER: Grassi F
PROVIDER: S-EPMC1986617 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Grassi Francesco F Tell Gianluca G Robbie-Ryan Michaela M Gao Yuhao Y Terauchi Masakazu M Yang Xiaoying X Romanello Milena M Jones Dean P DP Weitzmann M Neale MN Pacifici Roberto R
Proceedings of the National Academy of Sciences of the United States of America 20070911 38
Increased production of tumor necrosis factor alpha (TNF) in the bone marrow (BM) in response to both oxidative stress and T cell activation contributes to the bone loss induced by estrogen deficiency, but it is presently unknown whether oxidative stress causes bone loss through T cells. Here we show that ovariectomy causes an accumulation in the BM of reactive oxygen species, which leads to increased production of TNF by activated T cells through up-regulation of the costimulatory molecule CD80 ...[more]