Ontology highlight
ABSTRACT:
SUBMITTER: Menale C
PROVIDER: S-EPMC7203631 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Menale Ciro C Robinson Lisa J LJ Palagano Eleonora E Rigoni Rosita R Erreni Marco M Almarza Alejandro J AJ Strina Dario D Mantero Stefano S Lizier Michela M Forlino Antonella A Besio Roberta R Monari Marta M Vezzoni Paolo P Cassani Barbara B Blair Harry C HC Villa Anna A Sobacchi Cristina C
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20190909 11
Controlling oxidative stress through the activation of antioxidant pathways is crucial in bone homeostasis, and impairments of the cellular defense systems involved contribute to the pathogenesis of common skeletal diseases. In this work we focused on the dipeptidyl peptidase 3 (DPP3), a poorly investigated ubiquitous zinc-dependent exopeptidase activating the Keap1-Nrf2 antioxidant pathway. We showed Dpp3 expression in bone and, to understand its role in this compartment, we generated a Dpp3 kn ...[more]