Induction of mammary gland ductal hyperplasias and carcinoma in situ following fetal bisphenol A exposure.
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ABSTRACT:
SUBMITTER: Murray TJ
PROVIDER: S-EPMC1987322 | biostudies-literature | 2007 Apr-May
REPOSITORIES: biostudies-literature
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Induction of mammary gland ductal hyperplasias and carcinoma in situ following fetal bisphenol A exposure.
Murray Tessa J TJ Maffini Maricel V MV Ucci Angelo A AA Sonnenschein Carlos C Soto Ana M AM
Reproductive toxicology (Elmsford, N.Y.) 20061024 3
Exposure of the fetus to excess estrogen is believed to increase the risk of developing breast cancer during adult life. Fetal exposure to low doses of the xenoestrogen bisphenol A resulted in long-lasting effects in the mouse mammary gland that were manifested during adult life. It enhanced sensitivity to estradiol, decreased apoptosis, increased the number of progesterone receptor-positive epithelial cells at puberty and increased lateral branching at 4 months of age. We now report that fetal ...[more]
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