Ontology highlight
ABSTRACT:
SUBMITTER: Lyons TR
PROVIDER: S-EPMC3888478 | biostudies-literature | 2011 Aug
REPOSITORIES: biostudies-literature
Lyons Traci R TR O'Brien Jenean J Borges Virginia F VF Conklin Matthew W MW Keely Patricia J PJ Eliceiri Kevin W KW Marusyk Andriy A Tan Aik-Choon AC Schedin Pepper P
Nature medicine 20110807 9
The prognosis of breast cancer in young women is influenced by reproductive history. Women diagnosed within 5 years postpartum have worse prognosis than nulliparous women or women diagnosed during pregnancy. Here we describe a mouse model of postpartum breast cancer that identifies mammary gland involution as a driving force of tumor progression. In this model, human breast cancer cells exposed to the involuting mammary microenvironment form large tumors that are characterized by abundant fibril ...[more]