Ontology highlight
ABSTRACT:
SUBMITTER: Ehlers MD
PROVIDER: S-EPMC1993808 | biostudies-literature | 2007 May
REPOSITORIES: biostudies-literature
Ehlers Michael D MD Heine Martin M Groc Laurent L Lee Ming-Chia MC Choquet Daniel D
Neuron 20070501 3
Synaptic activity regulates the postsynaptic accumulation of AMPA receptors over timescales ranging from minutes to days. Indeed, the regulated trafficking and mobility of GluR1 AMPA receptors underlies many forms of synaptic potentiation at glutamatergic synapses throughout the brain. However, the basis for synapse-specific accumulation of GluR1 is unknown. Here we report that synaptic activity locally immobilizes GluR1 AMPA receptors at individual synapses. Using single-molecule tracking toget ...[more]