Ontology highlight
ABSTRACT:
SUBMITTER: Jacobi UG
PROVIDER: S-EPMC1994123 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Jacobi Ulrike G UG Akkers Robert C RC Pierson Elisabeth S ES Weeks Daniel L DL Dagle John M JM Veenstra Gert Jan C GJ
The EMBO journal 20070816 17
In addition to TATA-binding protein (TBP), a key factor for transcription initiation, the metazoan-specific TBP-like factor TLF/TRF2 and the vertebrate-specific factor TBP2/TRF3 are known to be required for transcription of specific subsets of genes. We have combined an antisense-knockdown approach with transcriptome profiling to determine the significance and biological role of TBP-independent transcription in early gastrula-stage Xenopus laevis embryos. Here, we report that, although each of t ...[more]