Ontology highlight
ABSTRACT:
SUBMITTER: Combadiere C
PROVIDER: S-EPMC1994614 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Combadière Christophe C Feumi Charles C Raoul William W Keller Nicole N Rodéro Mathieu M Pézard Adeline A Lavalette Sophie S Houssier Marianne M Jonet Laurent L Picard Emilie E Debré Patrice P Sirinyan Mirna M Deterre Philippe P Ferroukhi Tania T Cohen Salomon-Yves SY Chauvaud Dominique D Jeanny Jean-Claude JC Chemtob Sylvain S Behar-Cohen Francine F Sennlaub Florian F
The Journal of clinical investigation 20071001 10
The role of retinal microglial cells (MCs) in age-related macular degeneration (AMD) is unclear. Here we demonstrated that all retinal MCs express CX3C chemokine receptor 1 (CX3CR1) and that homozygosity for the CX3CR1 M280 allele, which is associated with impaired cell migration, increases the risk of AMD. In humans with AMD, MCs accumulated in the subretinal space at sites of retinal degeneration and choroidal neovascularization (CNV). In CX3CR1-deficient mice, MCs accumulated subretinally wit ...[more]