Ontology highlight
ABSTRACT:
SUBMITTER: Sennlaub F
PROVIDER: S-EPMC3840491 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Sennlaub Florian F Auvynet Constance C Calippe Bertrand B Lavalette Sophie S Poupel Lucie L Hu Shulong J SJ Dominguez Elisa E Camelo Serge S Levy Olivier O Guyon Elodie E Saederup Noah N Charo Israel F IF Rooijen Nico Van NV Nandrot Emeline E Bourges Jean-Louis JL Behar-Cohen Francine F Sahel José-Alain JA Guillonneau Xavier X Raoul William W Combadiere Christophe C
EMBO molecular medicine 20131021 11
Atrophic age-related macular degeneration (AMD) is associated with the subretinal accumulation of mononuclear phagocytes (MPs). Their role in promoting or inhibiting retinal degeneration is unknown. We here show that atrophic AMD is associated with increased intraocular CCL2 levels and subretinal CCR2(+) inflammatory monocyte infiltration in patients. Using age- and light-induced subretinal inflammation and photoreceptor degeneration in Cx3cr1 knockout mice, we show that subretinal Cx3cr1 defici ...[more]