Ontology highlight
ABSTRACT:
SUBMITTER: Garcia-Bassets I
PROVIDER: S-EPMC1994663 | biostudies-literature | 2007 Feb
REPOSITORIES: biostudies-literature
Garcia-Bassets Ivan I Kwon Young-Soo YS Telese Francesca F Prefontaine Gratien G GG Hutt Kasey R KR Cheng Christine S CS Ju Bong-Gun BG Ohgi Kenneth A KA Wang Jianxun J Escoubet-Lozach Laure L Rose David W DW Glass Christopher K CK Fu Xiang-Dong XD Rosenfeld Michael G MG
Cell 20070201 3
Nuclear receptors undergo ligand-dependent conformational changes that are required for corepressor-coactivator exchange, but whether there is an actual requirement for specific epigenetic landmarks to impose ligand dependency for gene activation remains unknown. Here we report an unexpected and general strategy that is based on the requirement for specific cohorts of inhibitory histone methyltransferases (HMTs) to impose gene-specific gatekeeper functions that prevent unliganded nuclear recepto ...[more]