Ontology highlight
ABSTRACT:
SUBMITTER: Coppi A
PROVIDER: S-EPMC1995445 | biostudies-literature | 2005 Jan
REPOSITORIES: biostudies-literature
Coppi Alida A Pinzon-Ortiz Consuelo C Hutter Christina C Sinnis Photini P
The Journal of experimental medicine 20050101 1
The circumsporozoite protein (CSP) is the major surface protein of Plasmodium sporozoites, the infective stage of malaria. Although CSP has been extensively studied as a malaria vaccine candidate, little is known about its structure. Here, we show that CSP is proteolytically cleaved by a papain family cysteine protease of parasite origin. Our data suggest that the highly conserved region I, found just before the repeat region, contains the cleavage site. Cleavage occurs on the sporozoite surface ...[more]