Ontology highlight
ABSTRACT:
SUBMITTER: Mankouri HW
PROVIDER: S-EPMC1995734 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Mankouri Hocine W HW Ngo Hien-Ping HP Hickson Ian D ID
Molecular biology of the cell 20070801 10
CSM2, PSY3, SHU1, and SHU2 (collectively referred to as the SHU genes) were identified in Saccharomyces cerevisiae as four genes in the same epistasis group that suppress various sgs1 and top3 mutant phenotypes when mutated. Although the SHU genes have been implicated in homologous recombination repair (HRR), their precise role(s) within this pathway remains poorly understood. Here, we have identified a specific role for the Shu proteins in a Rad51/Rad54-dependent HRR pathway(s) to repair MMS-in ...[more]