Ontology highlight
ABSTRACT:
SUBMITTER: Kaur H
PROVIDER: S-EPMC4338413 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Kaur Hardeep H De Muyt Arnaud A Lichten Michael M
Molecular cell 20150201 4
The topoisomerase III (Top3)-Rmi1 heterodimer, which catalyzes DNA single-strand passage, forms a conserved complex with the Bloom's helicase (BLM, Sgs1 in budding yeast). This complex has been proposed to regulate recombination by disassembling double Holliday junctions in a process called dissolution. Top3-Rmi1 has been suggested to act at the end of this process, resolving hemicatenanes produced by earlier BLM/Sgs1 activity. We show here that, to the contrary, Top3-Rmi1 acts in all meiotic re ...[more]