Ontology highlight
ABSTRACT:
SUBMITTER: Heix J
PROVIDER: S-EPMC19985 | biostudies-literature | 1997 Mar
REPOSITORIES: biostudies-literature
Heix J J Zomerdijk J C JC Ravanpay A A Tjian R R Grummt I I
Proceedings of the National Academy of Sciences of the United States of America 19970301 5
Promoter selectivity for all three classes of eukaryotic RNA polymerases is brought about by multimeric protein complexes containing TATA box binding protein (TBP) and specific TBP-associated factors (TAFs). Unlike class II- and III-specific TBP-TAF complexes, the corresponding murine and human class I-specific transcription initiation factor TIF-IB/SL1 exhibits a pronounced selectivity for its homologous promoter. As a first step toward understanding the molecular basis of species-specific prom ...[more]