Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC2000395 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Li Yu Y Carroll Darin S DS Gardner Shea N SN Walsh Matthew C MC Vitalis Elizabeth A EA Damon Inger K IK
Proceedings of the National Academy of Sciences of the United States of America 20070927 40
Human disease likely attributable to variola virus (VARV), the etiologic agent of smallpox, has been reported in human populations for >2,000 years. VARV is unique among orthopoxviruses in that it is an exclusively human pathogen. Because VARV has a large, slowly evolving DNA genome, we were able to construct a robust phylogeny of VARV by analyzing concatenated single nucleotide polymorphisms (SNPs) from genome sequences of 47 VARV isolates with broad geographic distributions. Our results show t ...[more]